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6 April, 2020 - 14:08 By Kate Sweeney

‘Dr Data’ holds best medicine to fight COVID-19, says Cambridge academic

A globally feted Cambridge academic says Machine Learning and AI capability that mines more accurate data could prove the most vital aid to healthcare professionals seeking to more swiftly identify victims and save more lives in the COVID-19 pandemic.

Professor Mihaela van der Schaar has unveiled a potentially transformative working proof of concept that she has built using anonymised data from Public Health England.

It follows her call last week for governments to use machine learning and AI techniques to help in the fight against the killer virus. Her team is hungry for even more data to refine and accelerate the initiative.

Professor van der Schaar is John Humphrey Plummer Professor of Machine Learning, Artificial Intelligence and Medicine at the University of Cambridge and a Turing Fellow at The Alan Turing Institute in London, where she leads the effort on data science and machine learning for personalised medicine. She holds 35 granted US patents.

She says that just a week after making the technology call she and her team had received “amazing” encouragement, ideas, and proposals for collaboration.

They also received, courtesy of Public Health England, a set of (depersonalised) data on existing COVID-19 cases. 

She says: “Along with my team at the Cambridge Centre for AI in Medicine, I’ve spent the last few days training our models on this data. The results so far are extremely encouraging.

“Among other things, we wanted to demonstrate that machine learning techniques can accurately predict how COVID-19 will impact resource needs (ventilators, ICU beds, etc.) at the individual patient level and the hospital level, thereby giving a reliable picture of future resource usage and enabling healthcare professionals to make well-informed decisions about how these scarce resources can be used to achieve the maximum benefit.

“Based on the data we received from Public Health England we now have a proof-of-concept demonstrator showing that this can be done, in the form of a new system we call Adjutorium.”

Isn’t flattening the curve enough?

Professor van der Schaar believes not. She says: “Social policies can certainly help take the strain off healthcare systems around the world. But there’s no guarantee that certain individual hospitals won’t still be stretched well beyond capacity. 

“Additionally, these measures may not be properly observed by everyone, or may be relaxed slowly over time. It’s important to ensure that hospitals remain armed with information that will help them manage peaks in demand for resources like ICU beds or ventilators.

“Life-or-death choices will be made regarding the use of scarce resources like ventilators and ICU beds. If you are managing or working in a hospital, it would be incredibly helpful (but it’s currently not possible) to have a highly reliable picture of the likely usage status of these resources over time.”

She says the initiative can help answer the vital questions being raised by front line medical workers by “being smart about how we use existing data on hospital admissions, ICU admissions, use of ventilators, patient outcomes (e.g. discharge, mortality), and more. 

“If we have access to high-quality datasets containing such information, we can use machine learning to answer questions such as:-

  • Which patients are most likely to need ventilators within a week?
  • How many free ICU beds is this hospital likely to have in a week?
  • Which of these two patients will get the most benefit from going on a ventilator today?

“While these questions can reliably be answered using the machine learning techniques we’ve developed, I cannot emphasise enough that the decisions themselves will, of course, still be made by healthcare professionals on the basis of their organisation’s priorities and policies.”

Using Adjutorium, patients are given risk scores based on their likelihood of ICU admission or ventilator usage. These are then aggregated across the hospital to give a picture of future demand on resources.

The team received data for nearly 1,700 patients, and that number continues to increase because the dataset is updated daily. While the data was depersonalised, it includes basic information, lab results, hospitalisation details, risk factors and outcomes.

They fed this data to AutoPrognosis, a state-of-the-art automated machine learning framework that the team developed in 2018 (initially for cardiovascular issues, but subsequently also for cystic fibrosis and breast cancer, among others).

To predict mortality, they used data from 850 patients to train the model and then verified the accuracy using results from 197 other patients from the same dataset. 

For ICU admission prediction, they trained with data from 950 patients and verified with data from 285 patients. To predict need for ventilation, they trained with 810 patients and verified with 276 patients.

So, how did Adjutorium perform? “Simply put: it did really, really well,” says Professor van der Schaar.

“Once trained with patient data, Adjutorium was able to make highly accurate predictions about the patients whose data we used for verification. Crucially, we managed to do so much more accurately than existing and widely-used survival analysis techniques such as Cox regression or well-known indexes such as the Charlson comorbidity index.

“It’s also worth bearing in mind that Adjutorium achieved these results with a relatively small proportion of the data that could be gathered from COVID-19 cases globally. 

“The more data we have access to, the better we can train our models and improve their accuracy, and the more useful Adjutorium becomes.”

Next steps

Professor van der Schaar says: “The progress we’ve made so far is extremely encouraging: we now have a functioning proof of concept that demonstrates the potential use of machine learning in helping to manage scarce resources like ICU beds and ventilators. There’s still work to be done, though, and much of this will rely on continuing to receive new and high-quality data.

“Our immediate priority is to continue to validate the models we’ve developed. Doing so will bring us closer to finalising the system for usage by healthcare professionals.

“We also need to get our hands on new types of data that will make our existing models even more accurate. Specifically, we require longitudinal data that enables us to gain a deeper understanding of the progression of patients while they’re hospitalised (rather than irregularly-recorded ‘snapshots’ that show the state of affairs at specific times). Given how little is known about COVID-19, such data would provide valuable insights. 

“Additionally, we’re hoping for clearer data regarding the timing and effects of ventilators when used to treat patients. This would let us tell, for example, how long individual patients could or should have waited before ventilation in order to achieve the best possible outcomes.

“We will also be working with the NHS and Public Health England to transform our tools into a system that can easily be used and understood by healthcare professionals. 

“In this sense, interpretability is key: we want to ensure that decision-makers can debug and analyse the information generated by our system.”

• To learn more, visit www.vanderschaar-lab.com/

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