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16 November, 2017 - 12:23 By Tony Quested

Cambridge human cell pioneer raises £350k seed funding

Elpis BioMed Dr Mark Kotter

A Cambridge University spin-out has raised £350k seed cash to progress a game-changing new technology platform for generating human cell types.

Backed by a world-class investor team including BioMedTech influencers Jonathan Milner and Darrin Disley, startup Elpis BioMed is being tipped as a potential global great in the push for personalised medicines.

Elpis BioMed is applying its disruptive and proprietary direct cell reprogramming platform to produce pure, mature and highly consistent batches of human cell types for research, toxicology and drug development.
The seed funding will allow the business to bring its human cell products and services to market.

The investor team is led by Jonathan Milner, with co-investments from Darrin Disley, Weslie Janeway and Nikolaus Starzacher. 

The funds will directly be used to grow the company’s catalogue of off-the-shelf human cell type products and expand its service offerings, marking its first step towards more complex products, including human organ-on-chip models, and cell-based therapies.

The use of human cells is becoming increasingly important in the context of research, toxicology, and drug discovery. Differences between commonly used cell and animal models and human biology contribute to high attrition rates at late stages of drug development.

Primary human cells remain restricted with respect to availability and lack consistency. Advances in human stem cell technology promised to increase the options available.

However, the elaborate culture protocols required for traditional ‘directed differentiation’ of stem cells into desired target cells result in limited scalability and considerable batch-to-batch variation, often yielding immature, foetal-like cells with a fundamentally different phenotype to that of mature cells in the human body.

Elpis’ proprietary cell reprogramming platform ‘OPTi-OX’ (optimised, inducible over-expression), overcomes the hurdles of availability, consistency, and maturity. It enables highly controlled, efficient, and scalable direct reprogramming of human stem cells into homogeneous target cell populations with minimal batch-to-batch variation. 

Elpis’ manufacturing approach reduces the time required to generate desired cell types from months to days and offers a reliable source of somatic human cell types that is amenable to high-throughput applications.

Elpis’ technology is already generating skeletal muscle cells, blood precursors, neuronal (cortical neurons) and glial cells. The company plans to expand its product offerings to human cells with distinct genetic backgrounds, e.g. from healthy and patient donors, as well as provide bespoke cells with synthetic mutations or gene insertions that meet specific research requirements.

It also offers strategic consulting services for tailored implementation of human cell assays in target validation, drug discovery, and screening processes.

Elpis is actively encouraging partnerships and joint ventures for generating novel cell types, complex in vitro models, such as 3D or organ-on-chip systems, and developing its cells for future therapeutic and personalised medicine approaches.

Elpis’ proprietary OPTi-OX platform was developed at the University of Cambridge and the Wellcome Trust Sanger Institute and published in Stem Cell Reports. 

The company was founded by Dr Mark Kotter, a clinician scientist at the University of Cambridge leading a translational research group with a focus on stem cells, human disease modelling, and regenerative medicine trials for cervical myelopathy, and Dr Gordana Apic, a serial entrepreneur in life science businesses.

Dr Kotter, scientific founder and CEO of Elpis said: “Elpis’ near-term goal is to allow every scientist to base their work on human cells, without the need of having particular expertise in stem cell biology. In the long term, we would like to develop our technology for clinical application.”

Jonathan Milner, co-founder and deputy chairman of Abcam added: “I’m thrilled to be backing Mark Kotter and his team at Elpis BioMed. Elpis’ approach to making human cells is truly disruptive – it reduces manufacturing time and at the same time increases purity by an order of magnitude. But what is most important: it allows for unprecedented levels of consistency and minimal batch-to-batch variability.”

Kiss Communications

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