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22 October, 2020 - 23:15 By Tony Quested

Major cancer treatment advance by STORM Therapeutics

STORM Therapeutics CEO Keith Blundy

STORM Therapeutics, a Cambridge biotech business focused on the discovery and development of small molecule therapies modulating RNA epigenetics, has made a fresh and significant breakthrough in a key cancer programme. And there’s more to come.

It reports that STC-15, its first-in-class drug candidate targeting METTL3, has been selected for development towards first in human clinical studies. The company intends to submit an IND application in 2021.

STC-15 is an orally bioavailable, small molecule METTL3 inhibitor targeting an entirely new mechanism of action (modulation of RNA epigenetics) to treat acute myeloid leukaemia (AML) and other solid and haematological cancers.

Clinical candidate selection demonstrates STORM's ground-breaking work on targeting RNA modifying enzymes for the development of new anti-cancer therapeutics. 

STORM has used state-of-the-art drug discovery capabilities, combined with unique analytical technologies specifically developed to target RNA epigenetics, to generate highly potent selective and orally bioavailable, small molecule inhibitors of METTL3 and other RNA modifying enzymes.

CEO Keith Blundy said: “STC-15, a highly potent and selective METTL3 inhibitor, is effective in leukaemia cells refractory to chemotherapy treatment. 

“This patient population will be incorporated into the initial clinical trials aiming to accelerate clinical proof of concept for patients with limited other options in addition to exploring combinations with standard of care. 

“STORM leads the global field of RNA modulation having demonstrated in vivo proof of concept activity of the first RNA methyltransferase inhibitor in relevant animal models for myeloid and solid tumours.

“METTL3 is one of two programmes from the STORM platform to show in vivo activity, with others to follow.”

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