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ARM Innovation Hub
5 December, 2016 - 13:32 By Kate Sweeney

Turbo-charged Horizon Discovery makes top 10 innovations in The Scientist

horizon, cambridge, gene editing, bioproduction, cell lines

One of gene editing pioneer Horizon Discovery’s key portfolio products has been included in The Scientist’s top 10 innovations for the fourth successive year.

The Cambridge UK business has been honoured for its TurboGFP tagged HAP1 cell lines; the technology enables researchers to study proteins at the endogenous level in live cell assays. 

The cells combine three leading technologies: CRISPR Cas9 gene editing; the HAP1 cell line; and TurboGFP™, an early maturation fluorescence protein from Evrogen.

Although gene editing techniques and technologies are now readily available, the processes are still not straightforward and can be costly in terms of time and resources. 

All of the award-winning products in Horizon’s portfolio have been designed to provide researchers with access to the latest gene editing technologies, effectively democratising gene editing. These products enable scientists to quickly confirm their findings or advance their theories using Horizon’s highly characterised gene-edited cell lines.

Horizon Discovery Group CEO, Dr Darrin Disley (above), said: “We are delighted that cutting edge technology provided by Horizon is being recognised at the international level and is assisting scientists worldwide to further their research.

“To have products included in the Top 10 Innovations of the year for the fourth time illustrates Horizon’s continued dedication to innovation, and developing world leading gene editing products and services.”

Dr Daniel Lackner, lead scientist behind the TurboGFP tagged HAP1 technology, added: “The two strongest points for these reporter cell lines are: A) Endogenous tagging allows for protein expression at physiological levels avoiding over-expression artefacts and B) all of the protein of interest will carry the fluorescent tag.

“Consequently, these reporter cells could really impact the study of protein localisation, as accurate reporters in high-throughput screening approaches, especially for live cell assays.”

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