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25 April, 2013 - 09:02 By News Desk

Method for dental pulp cryopreservation

Method for dental pulp cryopreservation

An Italian public corporation committed to healthcare and translational medicine has developed a simpler and cheaper method for cryopreserving the pulp of a non-exfoliated deciduous tooth, in order to isolate stem cells after cryopreservation.

The corporation is looking for industrial partners interested in licensing agreement or co-development and application of the new method.

Adult stem cells are an inexhaustible source of multipotent cells, which can differentiate if required into various cell lines. Thanks to these properties, adult stem cells can be used in the field of regenerative medicine for various purposes. A particular source of stem cell is the dental pulp.

The stem cells of the dental pulp (DPSC) can give rise to different cells of mesenchymal origin, such as osteoblasts, adipocytes, chondrocytes, muscle cells. Currently, the applications that make use of stem cells deriving from dental pulp are focused on bone regeneration both in the dental and maxilla - facial field and in the orthopedic field.

Current methods for preserving and banking dental pulp stem cells include steps in which dental pulp stem cells are recovered from the tooth, amplified and then stored in liquid nitrogen.

The present invention provides a simpler and cheaper method for cryopreserving the dental pulp and the stem cells contained therein. The method ensures good results in terms of post-thawing recovery percentages and of vitality of the cells, taking into particular consideration their proliferative and differentiative capacity.

The perforation in the tooth is made with a laser that removes selectively portions of dental enamel and of dentine in order to access the root canal without overheating the dental pulp. This contributes to ensure the integrity of the cryopreserved dental tissue, the absence of bacterial contamination and the high recover percentage of stem cells.

Innovative Aspects

Lower risk of bacterial contamination of the dental pulp and of the stem cells. Ensures integrity of the cryopreserved dental tissue and high recovery percentage of stem cells.

Type of partner sought: Industry

Specific area of activity of the partner: biobanking, regenerative medicine Task to be performed by the partner sought: co-development, application of the technology

Ref: 13 IT 54W2 3S8B

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